Conditional generation of free radicals by selective activation of alkoxyamines: towards more effective and less toxic targeting of brain tumors-Reference-Cited by-同舟云学术

Conditional generation of free radicals by selective activation of alkoxyamines: towards more effective and less toxic targeting of brain tumors

Published:2023 Issue:29 Volume:14 Page:7988-7998
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Piris Patricia¹^ORCID,Buric Duje¹,Yamasaki Toshihide²^ORCID,Huchedé Paul³,Rossi Maïlys¹,Matteudi Mélanie¹,Montero Marie-Pierre¹^ORCID,Rodallec Anne¹,Appay Romain⁴,Roux Christine¹,Combes Sébastien¹⁵,Pasquier Eddy¹,Castets Marie³,André Nicolas¹⁶,Brémond Paul¹⁵^ORCID,Carré Manon¹^ORCID

Affiliation:

1. Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Université UM105, Institut Paoli Calmettes – Faculté de Pharmacie, Marseille, France

2. Institut de Chimie Radicalaire, CNRS UMR7273, Aix-Marseille Université – Faculté des Sciences, Marseille, France

3. Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Lyon, France

4. Service D'anatomie Pathologique et de Neuropathologie, Hôpital de La Timone, Assistance Publique-Hôpitaux de Marseille (APHM), Marseille, France

5. DOSynth Platform, Centre de Recherche en Cancérologie de Marseille (CRCM), Faculté de Pharmacie, Marseille, France

6. Service D'Hématologie & Oncologie Pédiatrique, Hôpital de La Timone, Assistance Publique-Hôpitaux de Marseille (APHM), Marseille, France

Abstract

Our study at the chemistry–biology interface characterized a new alkoxyamine active against glioblastoma and medulloblastoma cancer cells.

Funder

Groupement des Entreprises Françaises dans la lutte contre le Cancer

Ligue Contre le Cancer

Canceropôle PACA

Aix-Marseille Université

Institut National Du Cancer

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01315D

Reference22 articles.

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5. Alkoxyamines: a new family of pro-drugs against cancer. Concept for theranostics