2-Pyridinylmethyl borrowing: base-promoted C-alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp3)

2-Pyridinylmethyl borrowing: base-promoted C-alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp3)–C(sp3) bonds

Published:2022 Issue:2 Volume:9 Page:299-304
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Hong Chuan-Ming¹,Zou Fei-Fei¹,Zhuang Xin¹,Luo Zhen¹,Liu Zheng-Qiang¹,Ren Li-Qing¹,Li Qing-Hua¹,Liu Tang-Lin¹^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Abstract

2-Pyridinylmethyl Borrowing: Transition-metal-free 2-pyridinylmethyl borrowing C-alkylation of alcohols access to ketones is developed. This unstrained C(sp3)–C(sp3) bonds cleavage of unactivated alcohols avoids the use of transition metals.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Venture and Innovation Support Program for Chongqing Overseas Returnees

Natural Science Foundation of Chongqing

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01446C

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