Stereoselective synthesis of oxime containing Pd(<scp>ii</scp>) compounds: highly effective, selective and stereo-regulated cytotoxicity against carcinogenic PC-3 cells-Reference-Cited by-同舟云学术

Stereoselective synthesis of oxime containing Pd(ii) compounds: highly effective, selective and stereo-regulated cytotoxicity against carcinogenic PC-3 cells

Published:2022 Issue:34 Volume:51 Page:12812-12828
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

de la Cueva-Alique Isabel¹,de la Torre-Rubio Elena¹,Muñoz-Moreno Laura²,Calvo-Jareño Alicia¹,Pérez-Redondo Adrián¹,Gude Lourdes¹^ORCID,Cuenca Tomás¹,Royo Eva¹^ORCID

Affiliation:

1. Universidad de Alcalá, Instituto de Investigación Química “Andrés M. del Río” (IQAR), Departamento de Química Orgánica y Química Inorgánica, 28805 Alcalá de Henares, Madrid, Spain

2. Universidad de Alcalá, Facultad de Medicina y Ciencias de la Salud, Departamento de Biología de Sistemas, 28805 Alcalá de Henares, Madrid, Spain

Abstract

Configurationally stable amino oxime oximato Pd(ii) enantiomers 2a and 2a′ show stereo-dependent and selective cytotoxicity against a variety of cancer cells, with IC50 values up to 80 times better than that of cisplatin.

Funder

Ministerio de Ciencia e Innovación

Ministerio de Economía y Competitividad

Comunidad de Madrid

Universidad de Alcalá

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT01403C

Reference122 articles.