Intrinsic fluorescence properties of antimalarial pyrido[1,2-a]benzimidazoles facilitate subcellular accumulation and mechanistic studies in the human malaria parasite Plasmodium falciparum
Author:
Affiliation:
1. Department of Chemistry
2. University of Cape Town
3. Rondebosch 7701
4. South Africa
5. Institute of Infectious Disease and Molecular Medicine
6. South African Medical Research Council Drug Discovery and Development Research Unit
Abstract
Intrinsic fluorescence properties, docking and a hemozoin inhibition assay were employed to study the mechanism of action of two structurally related pyrido-[1,2-a]benzimidazole derivatives.
Funder
Medicines for Malaria Venture
Merck KGaA
South African Medical Research Council
National Institute of Allergy and Infectious Diseases
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01730B
Reference47 articles.
1. Antimalarial Pyrido[1,2-a]benzimidazoles
2. Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model
3. How were new medicines discovered?
4. Chemoproteomic approaches to drug target identification and drug profiling
5. Chemical genetics of Plasmodium falciparum
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