The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage

Author:

Karch Kelly R.12345ORCID,Langelier Marie-France6789,Pascal John M.6789,Garcia Benjamin A.12345

Affiliation:

1. Department of Biochemistry and Molecular Biophysics

2. Epigenetics Institute

3. Perelman School of Medicine

4. University of Pennsylvania

5. Philadelphia

6. Department of Biochemistry and Molecular Medicine

7. Université de Montréal

8. Montréal

9. Canada

Abstract

Histone ADP-ribosylation sites were identified and quantified in vivo upon DNA damage insult using mass spectrometry.

Funder

Canadian Institutes of Health Research

National Cancer Institute

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

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