A regulatory mechanism of a stepwise osteogenesis-mimicking decellularized extracellular matrix on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells-Reference-Cited by-同舟云学术

A regulatory mechanism of a stepwise osteogenesis-mimicking decellularized extracellular matrix on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Published:2022 Issue:32 Volume:10 Page:6171-6180
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Xu Fei¹²³,Zheng Ziran¹²³,Yao Mianfeng¹²³,Zhu Feiya¹,Shen Ting¹,Li Jiang¹²³,Zhu Chao¹²³,Yang Tianru¹,Shao Mengying¹,Wan Zicheng⁴,Fang Changyun¹²³^ORCID

Affiliation:

1. Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China

2. Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, Hunan, China

3. Institute of Oral Precancerous Lesions, Central South University, Changsha, Hunan, China

4. Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Abstract

14d-ECM secreted by BMSCs promotes the osteogenic differentiation of BMSCs. The underlying mechanism may be related to COL4A2 in 14d-ECM via activation of the FAK/PI3K/AKT signaling pathway.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00721E

Reference50 articles.

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2. Chitosan based polymer/bioglass composites for tissue engineering applications