Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity-Reference-Cited by-同舟云学术

Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity

Published:2016 Issue:25 Volume:14 Page:5951-5955
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Brown Carla E.¹²³⁴,McNulty James¹²³⁴,Bordón Claudia⁵⁶⁷⁸⁹,Yolken Robert⁵⁶⁷⁸⁹,Jones-Brando Lorraine⁵⁶⁷⁸⁹

Affiliation:

1. Department of Chemistry and Chemical Biology

2. McMaster University

3. Hamilton

4. Canada L8S 4M1

5. Stanley Division of Developmental Neurovirology

6. Department of Pediatrics

7. Johns Hopkins University School of Medicine

8. Baltimore

9. USA

Abstract

A novel method for the preparation of 2-carboxyl-3-aryl quinoline derivatives from anilines, ethyl glyoxalate and enol ethers as phenylacetaldehyde surrogates is reported.

Funder

Natural Sciences and Engineering Research Council of Canada

Stanley Medical Research Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01083K

Reference37 articles.

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3. Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

4. Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

5. A Multicomponent Coupling Sequence for Direct Access to Substituted Quinolines

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