A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines-Reference-Cited by-同舟云学术

A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines

Published:2015 Issue:28 Volume:13 Page:7664-7672
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Melzer Benedikt¹²³⁴,Bracher Franz¹²³⁴

Affiliation:

1. Department of Pharmacy – Center for Drug Research

2. Ludwig-Maximilians University

3. D-81377 Munich

4. Germany

Abstract

Regioselective direct metalation of alkoxy isoquinolines with the Knochel–Hauser base, followed by trapping with aromatic aldehydes opens a new entry to benzylisoquinoline and oxoaporphine alkaloids.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00926J

Reference46 articles.

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2. M. Shamma , The isoquinoline alkaloids: chemistry and pharmacology, Academic Press, 1972

3. Alkaloids of Thalictrum XXXI. Synthesis of Rugosinone

4. The Synthesis of Thalmicrinone, a Confirmation of Structure

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