Synthesis of a sacubitril precursor <i>via</i> the construction of one-pot chemoenzymatic cascades-Reference-Cited by-同舟云学术

Synthesis of a sacubitril precursor via the construction of one-pot chemoenzymatic cascades

Published:2024 Issue:10 Volume:14 Page:2817-2824
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Chen Long¹²,Qu Ge²³⁴^ORCID,Cai Zhiqiang¹^ORCID,Yuan Bo²³⁴^ORCID,Sun Zhoutong²³⁴^ORCID

Affiliation:

1. School of Pharmacy, Changzhou University, Changzhou 213164, Jiangsu, P. R. China

2. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China

3. Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, P. R. China

4. National Innovation Center for Synthetic Biotechnology, 32 West 7th Avenue, Tianjin 300308, P. R. China

Abstract

A key precursor of sacubitril was synthesized with excellent diastereoselectivity via the construction of three one-pot enzymatic cascades.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CY/D4CY00145A

Reference32 articles.

1. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

2. Dicarboxylic Acid Dipeptide Neutral Endopeptidase Inhibitors

3. Synthesis of a Precursor to Sacubitril Using Enabling Technologies

4. Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow

5. Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of Sacubitril

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