Robust synthesis of 2′-azido modified RNA from 2′-amino precursors by diazotransfer reaction-Reference-Cited by-同舟云学术

Robust synthesis of 2′-azido modified RNA from 2′-amino precursors by diazotransfer reaction

Published:2022 Issue:39 Volume:20 Page:7845-7850
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Moreno Sarah¹,Ramos Pittol José M.²^ORCID,Hartl Markus²^ORCID,Micura Ronald¹^ORCID

Affiliation:

1. Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria

2. Institute of Biochemistry, Center for Chemistry and Biomedicine (CCB) Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria

Abstract

One-step conversion chemistry makes RNA with internal site-specific 2′-azido modifications readily accessible from 2′-amino RNA; it is significantly more efficient compared to thus far used phosphotriester chemistry to generate such RNA.

Funder

Austrian Science Fund

Österreichische Forschungsförderungsgesellschaft

Vienna Science and Technology Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01560A

Reference49 articles.

1. A Comparative Study of Bioorthogonal Reactions with Azides

2. Bioorthogonal chemistry

3. Covalent labeling of nucleic acids

4. A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

5. Site-specific terminal and internal labeling of RNA by poly(A) polymerase tailing and copper-catalyzed or copper-free strain-promoted click chemistry

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