A bis-indole/carbazole based C5-curcuminoid fluorescent probe with large Stokes shift for selective detection of biothiols and application to live cell imaging

Author:

Bhattacharjee Pinaki12345,Chatterjee Sourav12345,Achari Anushree12345,Saha Abhijit62345,Nandi Debkumar12345,Acharya Chiranjit12345,Chatterjee Kasturi7345,Ghosh Surajit62345ORCID,Swarnakar Snehasikta7345,Jaisankar Parasuraman12345ORCID

Affiliation:

1. Laboratory of Catalysis and Chemical Biology

2. Department of Organic and Medicinal Chemistry

3. CSIR-Indian Institute of Chemical Biology

4. Kolkata - 700 032

5. India

6. Chemistry-Biology Interface Laboratory

7. Cancer Biology and Inflammatory Disorder Division

Abstract

A series of heterocyclic C5-Curcuminoid (PJ1–PJ6) having large Stokes shift (Δλ= 104–173 nm) have been synthesized under the microwave irradiation andPJ1has been utilized for selective detection of thiols in A375 cells and apoptosis in AGS cells.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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