Tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the synthesis of S-linked glycosides and glyco-conjugates

Abstract

Tri-isopropylsilyl thio-glycosides (TIPS S-glycosides), readily synthesized from glycosyl halides, glycosyl acetates, or p-methoxyphenyl glycosides, were in one-pot de-silylated and S-alkylated, -acylated, or -glycosylated in high yields and short time.