Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents-Reference-Cited by-同舟云学术

Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents

Published:2020 Issue:23 Volume:49 Page:7852-7861
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Martín-Encinas Endika¹²³⁴⁵,Conejo-Rodríguez Verónica⁶⁷⁸⁹⁵^ORCID,Miguel Jesús A.⁶⁷⁸⁹⁵^ORCID,Martínez-Ilarduya Jesús M.⁶⁷⁸⁹⁵^ORCID,Rubiales Gloria¹²³⁴⁵^ORCID,Knudsen Birgitta R.¹⁰¹¹¹²¹³^ORCID,Palacios Francisco¹²³⁴⁵^ORCID,Alonso Concepción¹²³⁴⁵^ORCID

Affiliation:

1. Department of Organic Chemistry I

2. Faculty of Pharmacy

3. University of Basque Country (UPV/EHU)

4. Vitoria-Gasteiz

5. Spain

6. IU CINQUIMA/Química Inorgánica

7. Faculty of Science

8. University of Valladolid

9. Valladolid

10. Department of Molecular Biology and Genetics and Interdisciplinary Nanoscience Center (iNANO)

11. University of Aarhus

12. Aarhus

13. Denmark

Abstract

Gold(i) increases the cytotoxicity of phosphine sulfide quinolines against cancer cell lines, while heterocycles maintain the TopI inhibitory activity.

Funder

Ministerio de Ciencia, Innovación y Universidades

Agencia Estatal de Investigación

European Regional Development Fund

Ministerio de Economía y Competitividad

Eusko Jaurlaritza

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01467B