The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response
Author:
Affiliation:
1. Departments of Chemistry and Immunology
2. The Skaggs Institute for Chemical Biology
3. The Worm Institute for Research and Medicine (WIRM)
4. The Scripps Research Institute
5. La Jolla
Abstract
The anti-αGal antibody response induced by a happen-conjugate can discriminate between closely related αGal epitopes.
Funder
National Center for Advancing Translational Sciences
National Institute on Drug Abuse
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00448F
Reference38 articles.
1. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1----3Gal epitope in primates.
2. Human natural anti-alpha-galactosyl IgG. II. The specific recognition of alpha (1----3)-linked galactose residues.
3. A unique natural human IgG antibody with anti-alpha-galactosyl specificity.
4. One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody
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