Synthesis, characterization and antitumor activity of novel tetrapodal 1,4-dihydropyridines: p53 induction, cell cycle arrest and low damage effect on normal cells induced by genotoxic factor H2O2-Reference-Cited by-同舟云学术

Synthesis, characterization and antitumor activity of novel tetrapodal 1,4-dihydropyridines: p53 induction, cell cycle arrest and low damage effect on normal cells induced by genotoxic factor H2O2

Published:2016 Issue:47 Volume:6 Page:40900-40910
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mohamed Magda F.¹²³⁴⁵,Darweesh Ahmed F.⁶²³⁴⁵,Elwahy Ahmed H. M.⁶²³⁴⁵,Abdelhamid Ismail A.⁶²³⁴⁵

Affiliation:

1. Chemistry Department (Biochemistry Branch)

2. Faculty of Science

3. Cairo University

4. Giza

5. Egypt

6. Chemistry Department

Abstract

Synthesis of novel tetrakis(2,6-dimethyl-4-phenyl-1,4-dihydropyridinyl)methanes5a–dby acid-catalyzed condensation of the tetrakis-aldehydes6a–dwith eight equivalents of 3-aminobut-2-enenitrile2is reported. Antitumor activities of compounds5a–dwere also investigated.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA04974E

Reference77 articles.

1. Nitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, Nitrofurantoin and naphthalene

2. The oxidative aromatization of Hantzsch 1,4-dihydropyridines by molecular oxygen using surface functionalized silica supported cobalt catalysts

3. A new protocol to synthesize 1,4-dihydropyridines by using 3,4,5-trifluorobenzeneboronic acid as a catalyst in ionic liquid: synthesis of novel 4-(3-carboxyl-1H-pyrazol-4-yl)-1,4-dihydropyridines

4. Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines by SiO2/P2O5-SeO2under Mild and Heterogeneous Conditions

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