Targeting bacterial biofilms via surface engineering of gold nanoparticles

Author:

Giri Karuna1234,Rivas Yepes Laura52346,Duncan Bradley7894,Kolumam Parameswaran Praveen5234,Yan Bo7894ORCID,Jiang Ying7894,Bilska Marcela52346,Moyano Daniel F.7894,Thompson Michael A.5234,Rotello Vincent M.7894,Prakash Y. S.52346

Affiliation:

1. Department of Biochemistry and Molecular Biology

2. Mayo Clinic

3. Rochester

4. USA

5. Department of Anesthesiology

6. Department of Physiology & Biomedical Engineering

7. Department of Chemistry

8. University of Massachusetts Amherst

9. Amherst

Abstract

Bacterial biofilms are associated with persistent infections and antibiotics resistance which substantially complicate patient care. Surface engineering of nanoparticles represents a novel and unconventional approach to disrupt biofilms and target bacterial pathogens.

Funder

National Center for Advancing Translational Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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