Transition-metal-free, mild and efficient ring expansion of amino acid derivatives: facile access to densely functionalized azepines

Author:

Zhang Xingjie1ORCID,Wang Xue1,Jiao Chenchen1,Zhao Jie1,Liu Xiaopan1,Zhang Guisheng1ORCID

Affiliation:

1. Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University (HNU), 46 East of Construction Road, Xinxiang, Henan 453007, China

Abstract

A mild, practical and efficient approach for the synthesis of valuable azepine products was achieved by the ring expansion of easily accessible amino acid derivatives.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

China Postdoctoral Science Foundation

Henan Normal University

Natural Science Foundation of Henan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference47 articles.

1. B.Renfroe , C.Harrington and G. R.Proctor , Heterocyclic Compounds: Azepines , Wiley & Interscience , New York , 1984

2. J. B.Bremner and S.Samosorn , Comprehensive Heterocyclic Chemistry III , Elsevier , Oxford, U.K. , 2008 , vol. 13 , pp. 1–43

3. Chemical Studies on New Stemona Alkaloids, IV. Studies on New Alkaloids from Stemona tuberosa

4. Novel azepine derivatives from the pungent mushroom

5. Azepine derivatives from toadstools: The development of new syntheses for 3H-and 4H-azepines

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