Double asymmetric intramolecular aza-Michael reaction: a convenient strategy for the synthesis of quinolizidine alkaloids-Reference-Cited by-同舟云学术

Double asymmetric intramolecular aza-Michael reaction: a convenient strategy for the synthesis of quinolizidine alkaloids

Published:2021 Issue:40 Volume:19 Page:8740-8745
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Torres Javier¹,Escolano Marcos¹,Alzuet-Piña Gloria²^ORCID,Sánchez-Roselló María¹,del Pozo Carlos¹^ORCID

Affiliation:

1. Department of Organic Chemistry, University of Valencia, Vicente Andrés Estellés s/n, 46100-Burjassot-Valencia, Spain

2. Department of Inorganic Chemistry, University of Valencia, Vicente Andrés Estellés s/n, 46100-Burjassot-Valencia, Spain

Abstract

A new strategy for the asymmetric synthesis of the quinolizidine skeleton via double intramolecular aza-Michael reaction of sulfinyl amines bearing a bis-enone moiety is described. This is the shortest route towards quinolizidines reported to date.

Funder

Ministerio de Educación, Cultura y Deporte

Generalitat Valenciana

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01488A

Reference63 articles.

1. Quinolizidine Alkaloids from Cylicomorpha solmsii

2. Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids

3. Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms

4. Quinolizidine Alkaloids with Antiviral and Insecticidal Activities from the Seeds of Sophora tonkinensis Gagnep

5. Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer

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