Nine days extended release of adenosine from biocompatible MOFs under biologically relevant conditions-Reference-Cited by-同舟云学术

Nine days extended release of adenosine from biocompatible MOFs under biologically relevant conditions

Published:2022 Issue:5 Volume:10 Page:1342-1351
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

El-Mehalmey Worood A.¹²,Latif Najma³,Ibrahim Ahmed H.¹,Haikal Rana R.¹^ORCID,Mierzejewska Paulina⁴,Smolenski Ryszard T.⁴,Yacoub Magdi H.²³,Alkordi Mohamed H.¹^ORCID

Affiliation:

1. Center for Materials Science, Zewail City of Science and Technology, 6th of October, 12578, Giza, Egypt

2. Aswan Heart Center, Aswan, Egypt

3. Magdi Yacoub Institute, Heart Science Centre, Imperial College, Harefield, Uxbridge UB9 6JH, UK

4. Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland

Abstract

The stability of Zr–MOFs and the widely used Zn-based (ZIF-8) was investigated in physiologically relevant media, where detailed mechanistic investigations clearly demonstrated that the observed cytotoxicity of ZIF-8 is linked to its structural instability in simulant fluids, in contrast to the highly stable Zr-MOFs.

Funder

Zewail City of Science and Technology

Science and Technology Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01519B

Reference36 articles.

1. Regulation of Inflammation by Adenosine

2. Adenosine and Inflammation: Here, There and Everywhere