Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks
Author:
Affiliation:
1. Department of Chemistry and the Manitoba Institute for Materials
2. University of Manitoba
3. Winnipeg
4. Canada
5. Department of Chemistry
6. Kent State University
7. Kent
8. USA
Abstract
Pt(ii) complexes supported by chelating, multidentate ligands containing phenanthridine heterocycles are reported and shown to exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.
Funder
Research Manitoba
University of Manitoba
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01275K
Reference28 articles.
1. Platinum Compounds: a New Class of Potent Antitumour Agents
2. Cellular processing of platinum anticancer drugs
3. Metal Drugs and the Anticancer Immune Response
4. The status of platinum anticancer drugs in the clinic and in clinical trials
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