Identification and discrimination of binding sites of an organoruthenium anticancer complex to single-stranded oligonucleotides by mass spectrometry-Reference-Cited by-同舟云学术

Identification and discrimination of binding sites of an organoruthenium anticancer complex to single-stranded oligonucleotides by mass spectrometry

Published:2014 Issue:18 Volume:139 Page:4491-4496
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Liu Suyan¹²³⁴⁵,Wu Kui¹²³⁴⁵,Zheng Wei¹²³⁴⁵,Zhao Yao¹²³⁴⁵,Luo Qun¹²³⁴⁵,Xiong Shaoxiang¹²³⁴⁵,Wang Fuyi¹²³⁴⁵

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. CAS Key Laboratory of Analytical Chemistry for Living Biosystems

3. Beijing Centre for Mass Spectrometry

4. Institute of Chemistry

5. Chinese Academy of Sciences

Abstract

Top-down MS analysis provided sequential and complementary fragments, which is more efficient than ladder-sequencing MS in discriminating binding sites of a ruthenium anticancer complex bearing a bulky ligand to oligonucleotides.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/AN/C4AN00807C

Reference32 articles.

1. Inhibition of Cancer Cell Growth by Ruthenium(II) Arene Complexes

2. In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer

3. Structure, Recognition, and Processing of Cisplatin−DNA Adducts

4. Organometallic Ruthenium(II) Diamine Anticancer Complexes: Arene-Nucleobase Stacking and Stereospecific Hydrogen-Bonding in Guanine Adducts

5. Highly Selective Binding of Organometallic Ruthenium Ethylenediamine Complexes to Nucleic Acids: Novel Recognition Mechanisms

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