Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR<sup>WT</sup>/COX-2 inhibitors with docking studies-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR^WT/COX-2 inhibitors with docking studies

Published:2023 Issue:46 Volume:13 Page:32296-32320
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Reda Nada¹^ORCID,Elshewy Ahmed²³^ORCID,EL-Askary Hesham I.⁴^ORCID,Mohamed Khaled O.²⁵^ORCID,Helwa Amira A.¹^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6th of October City, Egypt

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt

3. Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University, New Galala 43713, Egypt

4. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt

5. Pharmaceutical Chemistry Department, Faculty of Pharmacy. Sinai University (Arish Branch), El Arish, Egypt

Abstract

A series of pyrimidine-5-carbonitriles was designed and synthesized as potential anti-cancer agents with dual EGFRWT/COX-2 inhibition. Compounds 4e and 4f disclosed the highest activity on all NCI60 cell lines.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA06088H

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