A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1

A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope

Published:2020 Issue:48 Volume:56 Page:6551-6554
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wang Jiaxing¹²³⁴⁵^ORCID,Ellis Beverly¹²³⁴⁵^ORCID,Zhou Bin¹²³⁴⁵^ORCID,Eubanks Lisa M.¹²³⁴⁵^ORCID,Blake Steven¹²³⁴⁵^ORCID,Janda Kim D.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Department of Immunology and Microbial Science

3. The Skaggs Institute for Chemical Biology

4. The Worm Institute for Research and Medicine (WIRM)

5. The Scripps Research Institute

Abstract

A double-conjugate fentanyl vaccine leveraging preformed anti-Gal antibodies significantly reduced the pain-relieving effect of fentanyl in mice.

Funder

National Institute on Drug Abuse

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02107E

Reference29 articles.

1. The Role of Science in Addressing the Opioid Crisis

2. Changes in Synthetic Opioid Involvement in Drug Overdose Deaths in the United States, 2010-2016

3. A REVIEW OF THE CHEMICAL FEATURES ASSOCIATED WITH STRONG MORPHINE-LIKE ACTIVITY

4. A review: Fentanyl and non-pharmaceutical fentanyls

5. Comparison of the Antinociceptive Response to Morphine and Morphine-Like Compounds in Male and Female Sprague-Dawley Rats

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl;Toxicology and Applied Pharmacology;2024-05

2. A conjugate vaccine strategy that induces protective immunity against arecoline;European Journal of Medicinal Chemistry;2024-03

3. Supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery;Chinese Chemical Letters;2024-02

4. Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020;Mass Spectrometry Reviews;2023-02-22

5. Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse;Neuroscience Bulletin;2022-05-15