Design and screening of SGK1, Src dual inhibitors using pharmacophore models, molecular docking, and molecular dynamics simulation-Reference-Cited by-同舟云学术

Design and screening of SGK1, Src dual inhibitors using pharmacophore models, molecular docking, and molecular dynamics simulation

Published:2020 Issue:41 Volume:44 Page:17815-17820
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Sun Chuan-ce¹²³⁴^ORCID,Zhang Li-chuan¹²³⁴,Gao Cheng-long¹²³⁴,Zhang Hao-ran¹²³⁴,Yu Ri-lei⁵⁶⁷⁸³^ORCID,Kang Cong-min¹²³⁴

Affiliation:

1. College of Chemical Engineering

2. Qingdao University of Science and Technology

3. Qingdao

4. China

5. Key Laboratory of Marine Drugs

6. Chinese Ministry of Education

7. School of Medicine and Pharmacy

8. Ocean University of China

Abstract

Serum and glucocorticoid-regulated protein kinase 1 that can promote the growth of tumor cells is highly expressed in many tumors. Sarcoma gene plays an important role in the pathogenesis of cancer and is an important kinase in tumor cell expression pathways.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ02249G

Reference23 articles.

1. Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic

2. Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund’s adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats

3. Spinal Serum-Inducible and Glucocorticoid-Inducible Kinase 1 Mediates Neuropathic Pain via Kalirin and Downstream PSD-95-Dependent NR2B Phosphorylation in Rats

4. EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency

5. Inhibition of Colonic Tumor Growth by the Selective SGK Inhibitor EMD638683

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