Mutation L1196M-induced conformational changes and the drug resistant mechanism of anaplastic lymphoma kinase studied by free energy perturbation and umbrella sampling
Author:
Affiliation:
1. School of Science, Shandong Jiaotong University
2. Jinan
3. China
4. Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
5. Shanghai
Abstract
Anaplastic lymphoma kinase (ALK) has been regarded as a promising drug target in the treatment of tumors and the mutation L1196M induces different levels of drug resistance toward the existing inhibitors.
Funder
National Natural Science Foundation of China
Shandong Jiaotong University
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CP/C7CP05418A
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3. Anaplastic Thyroid Cancers Harbor Novel Oncogenic Mutations of the ALK Gene
4. Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer
5. The anaplastic lymphoma kinase in the pathogenesis of cancer
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