Soft X-ray spectromicroscopy of human fibroblasts with impaired sialin function

Author:

Mansikkala Tuomas12ORCID,Kangas Salla M.3,Miinalainen Ilkka2,Angervaniva Pia3,Darin Niklas4,Blomqvist Maria5,Hinttala Reetta23,Huttula Marko1ORCID,Uusimaa Johanna36,Patanen Minna12ORCID

Affiliation:

1. Nano and Molecular Systems Research Unit, 90014 University of Oulu, PO Box 3000, Finland

2. Biocenter Oulu, 90014 University of Oulu, PO Box 5000, Finland

3. Research Unit of Clinical Medicine and Medical Research Center, Oulu University Hospital and University of Oulu, 90014 Oulu, Finland

4. Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden

5. Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sweden and Department of Clinical Chemistry, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden

6. Department of Paediatrics and Adolescent Medicine, Paediatric Neurology Unit, Oulu University Hospital, 90029 Oulu, Finland

Abstract

A comparative study of normal human fibroblasts and Salla disease patients' fibroblasts reveals changes in the soft X-ray spectroscopic signatures of disease cells. Synchrotron radiation imaging was performed for thin sections and grid-grown cells.

Funder

Biocenter, University of Oulu

Research Council of Finland

Tauno Tönningin Säätiö

Emil Aaltosen Säätiö

Lastentautien Tutkimussäätiö

Publisher

Royal Society of Chemistry (RSC)

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