New Fe(iii) and Co(ii) salen complexes with pendant distamycins: selective targeting of cancer cells by DNA damage and mitochondrial pathways-Reference-Cited by-同舟云学术

New Fe(iii) and Co(ii) salen complexes with pendant distamycins: selective targeting of cancer cells by DNA damage and mitochondrial pathways

Published:2016 Issue:22 Volume:45 Page:9345-9353
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Ali Asfa¹²³⁴,Kamra Mohini¹²³⁴,Bhan Arunoday⁵⁶⁷⁸,Mandal Subhrangsu S.⁵⁶⁷⁸,Bhattacharya Santanu¹²³⁴⁹

Affiliation:

1. Department of Organic Chemistry

2. Indian Institute of Science

3. Bangalore 560 012

4. India

5. Department of Chemistry and Biochemistry

6. The University of Texas at Arlington

7. Arlington

8. USA

9. Indian Association for the Cultivation of Science

Abstract

Distamycin like moieties conjugated with core Fe(iii) and Co(ii) based salens were synthesized and studied. The metal complexes showed better and differential activity toward cancer cell death.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C5DT04374C

Reference57 articles.

1. The molecular origin of DNA-drug specificity in netropsin and distamycin.

2. Binding of two distamycin A molecules in the minor groove of an alternating B–DNA duplex

3. Minor Groove Binder Distamycin Remodels Chromatin but Inhibits Transcription

4. Molecular structure of the netropsin-d(CGCGATATCGCG) complex: DNA conformation in an alternating AT segment

5. Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands

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