Armeniaspirol analogues with more potent Gram-positive antibiotic activity show enhanced inhibition of the ATP-dependent proteases ClpXP and ClpYQ-Reference-Cited by-同舟云学术

Armeniaspirol analogues with more potent Gram-positive antibiotic activity show enhanced inhibition of the ATP-dependent proteases ClpXP and ClpYQ

Published:2022 Issue:4 Volume:13 Page:436-444
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Darnowski Michael G.¹,Lanosky Taylor D.¹,Labana Puneet¹,Brazeau-Henrie Jordan T.¹,Calvert Nicholas D.¹,Dornan Mark H.¹,Natola Claudia¹,Paquette André R.¹,Shuhendler Adam J.¹^ORCID,Boddy Christopher N.¹^ORCID

Affiliation:

1. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5 Canada

Abstract

Antibiotics with fundamentally new mechanisms of action such as the armeniaspirols, which target the ATP-dependent proteases ClpXP and ClpYQ, must be developed to combat antimicrobial resistance.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00355K

Reference37 articles.

1. Isolation and Structural Elucidation of Armeniaspirols A-C: Potent Antibiotics against Gram-Positive Pathogens

2. Armeniaspiroles, a new class of antibacterials: antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A

3. Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria

4. Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus

5. The influence of drug-like concepts on decision-making in medicinal chemistry

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1. Systematic in vitro optimization of antimicrobial peptides against Escherichia coli;JAC-Antimicrobial Resistance;2024-07-03

2. Armeniaspirol analogues disrupt the electrical potential (ΔΨ) of the proton motive force;Bioorganic & Medicinal Chemistry Letters;2023-03

3. Synthesis of a Constitutional Isomer of Armeniaspirol A, Pseudoarmeniaspirol A, via Lewis Acid-Mediated Rearrangement;The Journal of Organic Chemistry;2022-11-02