Mononuclear iron(iii) complexes of tridentate ligands with efficient nuclease activity and studies of their cytotoxicity-Reference-Cited by-同舟云学术

Mononuclear iron(iii) complexes of tridentate ligands with efficient nuclease activity and studies of their cytotoxicity

Published:2015 Issue:47 Volume:13 Page:11445-11458
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tyagi Nidhi¹²³⁴,Chakraborty Ajanta⁵²³⁴,Singh Udai P.¹²³⁴,Roy Partha⁵²³⁴,Ghosh Kaushik¹²³⁴

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology Roorkee

3. Roorkee-247667

4. India

5. Department of Biochemistry

Abstract

Mono- and bis-chelated iron(iii) complexes derived from phenolato-based tridentate ligands have been synthesised and characterized. These complexes show electrostatic DNA interactions and efficient DNA cleavage via OH˙ radicals, and induce cytotoxicity in MCF7 cell lines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01623A

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