The sequestration mechanism as a generalizable approach to improve the sensitivity of biosensors and bioassays-Reference-Cited by-同舟云学术

The sequestration mechanism as a generalizable approach to improve the sensitivity of biosensors and bioassays

Published:2022 Issue:41 Volume:13 Page:12219-12228
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chamorro-Garcia Alejandro¹²^ORCID,Parolo Claudio³^ORCID,Ortega Gabriel⁴⁵,Idili Andrea²^ORCID,Green Joshua¹,Ricci Francesco²^ORCID,Plaxco Kevin W.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry University of California Santa Barbara (UCSB), Santa Barbara, CA 93106, USA

2. Dipartimento di Scienze e Tecnologie Chimiche, University of Rome, Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy

3. ISGlobal–Barcelona Institute for Global Health, Carrer del Rosselló 132, 08036 Barcelona, Spain

4. Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain

5. Precision Medicine and Metabolism Laboratory, CIC BioGUNE, Basque Research and Technology Alliance, Parque Tecnológico de Bizkaia, 48160 Derio, Spain

Abstract

We adapt sequestration, a naturally occurring mechanism by which cells modulate the sensitivity of many biological processes, into three different biosensors and bioassays to achieve steeper, more sensitive responses against a biomarker of kidney damage.

Funder

Ministerio de Ciencia e Innovación

Generalitat de Catalunya

H2020 Marie Skłodowska-Curie Actions

Ikerbasque, Basque Foundation for Science

Fondazione Umberto Veronesi

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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