Kinetics of the mechanically induced ibuprofen–nicotinamide co-crystal formation by in situ X-ray diffraction

Author:

Casali Lucia1,Carta Maria23,Michalchuk Adam A. L.14ORCID,Delogu Francesco23ORCID,Emmerling Franziska15ORCID

Affiliation:

1. Federal Institute for Materials Research and Testing, Richard-Willstätter-Straße 11, 12489 Berlin, Germany

2. Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, via Marengo 2, 09123 Cagliari, Italy

3. Center for Colloid and Surface Science (CSGI), Cagliari Research unit, Department of Chemistry, University of Florence, via della Lastruccia 3, 50019 – Sesto Fiorentino, FI, Italy

4. School of Chemistry, University of Birmingham, B15 2TT Edgbaston, Birmingham, UK

5. Department of Chemistry, Humboldt-Universität zu Berlin, 12489 Berlin, Germany

Abstract

Combined time-resolved in situ analysis and numerical modelling reveals details of mechanochemical reaction mechanisms.

Publisher

Royal Society of Chemistry (RSC)

Reference50 articles.

1. The Relevance of Crystal Forms in the Pharmaceutical Field: Sword of Damocles or Innovation Tools?

2. Ibuprofen Market Size | API Market | Demand, Price Chart, https://www.beroeinc.com/category-intelligence/ibuprofen-market/ , (accessed 10 November 2023)

3. Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances

4. Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation

5. Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug – Santos – 2019 – ChemMedChem – Wiley Online Library, https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201900040 , (accessed 10 November 2023)

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