First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP-Reference-Cited by-同舟云学术

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP

Published:2014 Issue:37 Volume:12 Page:7338-7344
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Chaolei¹²³⁴²,Wei Guoxiang¹²³⁴²,Yang Xue¹²³⁴²,Yao Hequan¹²³⁴²,Jiang Jieyun⁵⁶⁷⁸,Liu Jie¹²³⁹²,Shen Mingqin¹⁰¹¹,Wu Xiaoming¹²³⁴²,Xu Jinyi¹²³⁴²

Affiliation:

1. State Key Laboratory of Natural Medicines

2. China Pharmaceutical University

3. Nanjing 210009, PR China

4. Department of Medicinal Chemistry

5. Department of Microbiology

6. Immunology and Molecular Genetics

7. University of Kentucky College of Medicine

8. Lexington, USA

9. Department of Organic Chemistry

10. Jiangsu Provincial Institute of Traditional Chinese Medicine

11. Nanjing 210028, PR China

Abstract

The first total synthesis of S-(+)-XJP and R-(−)-XJP has been achieved via intramolecular Heck reaction. A latent functionality strategy was implemented to circumvent the racemization in this endeavor.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01470G

Reference24 articles.

1. A new isochroman-4-one derivative from the peel of Musa sapientum L. and its total synthesis

2. Total synthesis and antihypertensive activity of (±)7,8-dihydroxy-3-methyl-isochromanone-4

3. XJP-1, a novel ACEI, with anti-inflammatory properties in HUVECs

4. Suppression of endothelial cell adhesion by XJP-1, a new phenolic compound derived from banana peel

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