Synthesis of 2-deoxy-2,2-difluoro-α-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S-Reference-Cited by-同舟云学术

Synthesis of 2-deoxy-2,2-difluoro-α-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S

Published:2015 Issue:27 Volume:13 Page:7542-7550
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Thanna Sandeep¹²³⁴,Lindenberger Jared J.¹²³⁴,Gaitonde Vishwanath V.¹²³⁴,Ronning Donald R.¹²³⁴,Sucheck Steven J.¹²³⁴

Affiliation:

1. Department of Chemistry and Biochemistry

2. The University of Toledo

3. Toledo

4. USA 43606

Abstract

Mycobacterium tuberculosis (Mtb)GlgE is a genetically validated TB drug target involved in α-glucan biosynthesis. TheStreptomyces coelicolor (Sco)GlgEI-V279S variant described here is used as a model enzyme for structure-based inhibitor design.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00867K

Reference18 articles.

1. W. H. Organization, 2014

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4. Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE

5. Synthesis of a Poly-hydroxypyrolidine-Based inhibitor of Mycobacterium tuberculosis GlgE

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