PEG-copolymer-coated iron oxide nanoparticles that avoid the reticuloendothelial system and act as kidney MRI contrast agents

Author:

Gómez-Vallejo Vanessa1234ORCID,Puigivila María56274,Plaza-García Sandra56274,Szczupak Boguslaw891011ORCID,Piñol Rafael1213144,Murillo José L.1213144,Sorribas Victor1516174ORCID,Lou Gustavo1213144,Veintemillas Sabino181920214ORCID,Ramos-Cabrer Pedro56274ORCID,Llop Jordi1234ORCID,Millán Angel1213144ORCID

Affiliation:

1. Radiochemistry and Nuclear Imaging Group

2. CIC biomaGUNE

3. 20014 Donostia-San Sebastián

4. Spain

5. Magnetic Resonance Imaging Department

6. Molecular Imaging Unit

7. Donostia-San Sebastián

8. Department of Telecommunications and Teleinformatics

9. Wroclaw University of Science and Technology

10. 50-370 Wroclaw

11. Poland

12. ICMA

13. CSIC-Universidad de Zaragoza

14. 50009 Zaragoza

15. Departamento de Toxicología

16. Universidad de Zaragoza

17. 50013 Zaragoza

18. ICMM

19. CSIC

20. Sor Juana Inés de la Cruz 3

21. 28049 Madrid

Abstract

PEG coated magnetic nanocarriers avoid the reticuloendothelial system, and show an MRI contrast in the kidneys. The results are supported by SPECT, gamma-counting, MRI and TEM histology.

Funder

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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