Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations-Reference-Cited by-同舟云学术

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations

Published:2022 Issue:23 Volume:12 Page:14865-14882
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Nassar Ibrahim F.¹^ORCID,Abdel Aal Mohammed T.²,El-Sayed Wael A.³⁴,A. E Shahin Mahmoud²,Elsakka Elsayed G. E.⁵,Mokhtar Mahmoud Mohamed⁵,Hegazy Maghawry⁵,Hagras Mohamed⁶,Mandour Asmaa A.⁷,Ismail Nasser S. M.⁷^ORCID

Affiliation:

1. Faculty of Specific Education, Ain Shams University (ASU), 365 Ramsis Street, Abassia, Cairo, Egypt

2. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

3. Department of Chemistry, College of Science, Qassim University, Kingdom of Saudi Arabia

4. Photochemistry Department, National Research Centre, El-Behouth St., Dokki, Cairo, Egypt

5. Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

6. Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

7. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo 11835, Egypt

Abstract

A new set of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffolds (4–13) as well as the thioglycoside derivatives (14, 15) were designed, and synthesized as novel CDK2 targeting compounds.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA01968J

Reference45 articles.

1. Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold

2. The Protein Kinase Complement of the Human Genome

3. Protein kinases — the major drug targets of the twenty-first century?

4. Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity

5. Decoding molecular mechanism of inhibitor bindings to CDK2 using molecular dynamics simulations and binding free energy calculations

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