Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic-Reference-Cited by-同舟云学术

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

Published:2022 Issue: Volume: Page:
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Limbocker Ryan¹^ORCID,Errico Silvia²³^ORCID,Barbut Denise⁴^ORCID,Knowles Tuomas P. J.³⁵^ORCID,Vendruscolo Michele³^ORCID,Chiti Fabrizio²^ORCID,Zasloff Michael⁴⁶^ORCID

Affiliation:

1. Department of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, USA

2. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, Italy

3. Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK

4. Enterin Inc., 3624 Market Street, Philadelphia, Pennsylvania 19104, USA

5. Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK

6. MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20010, USA

Abstract

The natural products squalamine and trodusquemine are promising potential therapeutics against Alzheimer's, Parkinson's, and other neurodegenerative diseases for their ability to modulate protein aggregation processes and target protein misfolded oligomers that are toxic to neurons.

Funder

Army Research Laboratory

Regione Toscana

Frances and Augustus Newman Foundation

Defense Threat Reduction Agency

Università degli Studi di Firenze

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NP/D1NP00042J

Reference72 articles.

1. Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

2. Alzheimer's Association , Alzheimer's and Dementia , https://alz.org/alzheimer_s_dementia , accessed June 22, 2021

3. Alzheimer's Assoication , Dementia vs. Alzheimer's Disease , https://alz.org/alzheimers-dementia/difference-between-dementia-and-alzheimer-s , accessed June 22, 2021

4. American Parkinson Disease Association , What is Parkinson's Disease , https://www.apdaparkinson.org/what-is-parkinsons/ , accessed June 12, 2021

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Natural products targeting amyloid-β oligomer neurotoxicity in Alzheimer's disease;European Journal of Medicinal Chemistry;2024-10

2. Exploring the Therapeutic Potential of Phytoconstituents for Addressing Neurodegenerative Disorders;Central Nervous System Agents in Medicinal Chemistry;2024-08

3. Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntington’s disease;2024-07-22

4. Leveraging Machine Learning-Guided Molecular Simulations Coupled with Experimental Data to Decipher Membrane Binding Mechanisms of Aminosterols;Journal of Chemical Theory and Computation;2024-07-09

5. Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy;Ageing Research Reviews;2024-07