Probing the cooperative mechanism of the μ–δ opioid receptor heterodimer by multiscale simulation
Author:
Affiliation:
1. Faculty of Chemistry
2. Sichuan University
3. Chengdu
4. People's Republic of China
5. College of Management
6. Southwest University for Nationalities
7. Chengdu 610041
8. P. R. China
9. College of Computer Science
Abstract
The activation-cooperativity of the μ–δ opioid receptor heterodimer was probed by multiscale simulation coupled with a protein structure network.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP06652C
Reference120 articles.
1. Molecular signatures of G-protein-coupled receptors
2. Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors
3. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
4. Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism
5. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base
Cited by 23 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The World of GPCR dimers – Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements;Computational and Structural Biotechnology Journal;2023
2. Biased Activation Mechanism Induced by GPCR Heterodimerization: Observations from μOR/δOR Dimers;Journal of Chemical Information and Modeling;2022-11-15
3. Key Residues in δ Opioid Receptor Allostery Explored by the Elastic Network Model and the Complex Network Model Combined with the Perturbation Method;Journal of Chemical Information and Modeling;2022-09-08
4. Dynamics and Key Residues of?Opioid Receptor Investigated by AnisotropicNetwork Model;PROG BIOCHEM BIOPHYS;2022
5. Simulating Time-Resolved Dynamics of Biomolecular Systems;Comprehensive Pharmacology;2022
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3