Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides-Reference-Cited by-同舟云学术

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Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides

Published:2024 Issue:7 Volume:15 Page:2305-2309
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kamps Jos J. A. G.¹^ORCID,Zhang Dong¹,Claridge Timothy D. W.¹^ORCID,Schofield Christopher J.¹^ORCID

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford OX1 3TA, UK

Abstract

Unexpected reaction of enethiols to form 1,3-dithiolanes and mixed disulfides in DMSO occur through a common thioketone intermediate.

Funder

Biotechnology and Biological Sciences Research Council

Wellcome Trust

Cancer Research UK

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00157E

Reference28 articles.

1. Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

2. New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

3. Long-Term Clinical Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Peripheral Neuropathy

4. Epalrestat: An Aldose Reductase Inhibitor for the Treatment of Diabetic Neuropathy

5. The clinical efficacy of epalrestat combined with α-lipoic acid in diabetic peripheral neuropathy

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