Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson's disease-Reference-Cited by-同舟云学术

Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson's disease

Published:2021 Issue:17 Volume:12 Page:7816-7824
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

He Jianzheng¹²^ORCID,Li Xu³,Yang Shipei¹,Li Yaling¹²,Lin Xingyao⁴,Xiu Minghui³,Li Xuexiang⁵,Liu Yongqi¹⁴

Affiliation:

1. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China

2. College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China

3. College of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China

4. Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

5. College of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China

Abstract

Gastrodin feeding extends lifespan, improves antioxidant ability, and delays the onset of a Parkinson-like phenotypes in Pink1B9 mutant, but does not ameliorate the tau-induced neurobehavioral deficits in Drosophila melanogaster.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO00847A

Reference47 articles.

1. Drosophila melanogaster as a model system in the study of pharmacological interventions in aging

2. Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

3. Neural mechanisms of ageing and cognitive decline