Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications-Reference-Cited by-同舟云学术

Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications

Published:2015 Issue:8 Volume:6 Page:5006-5015
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guenther Dale C.¹²³⁴,Anderson Grace H.¹²³⁴⁵,Karmakar Saswata¹²³⁴,Anderson Brooke A.¹²³⁴,Didion Bradley A.⁶⁷⁴,Guo Wei⁶⁷⁴,Verstegen John P.⁶⁷⁴,Hrdlicka Patrick J.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Idaho

3. Moscow

4. USA

5. Department of Biological Sciences

6. MoFA

7. Verona

Abstract

Optimized Invader probes enable efficient (C₅₀ < 1 μM), fast (t₅₀ < 3 h), kinetically stable (>24 h), and single nucleotide specific recognition of DNA targets.

Funder

National Institute of General Medical Sciences

National Center for Research Resources

Office of Naval Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC01238D

Reference46 articles.

1. Triplex-Forming Oligonucleotides - Sequence-Specific DNA Ligands as Tools for Gene Inhibition and for Modulation of DNA-Associated Functions