A core–shell structured polyplex for efficient and non-toxic gene delivery-Reference-Cited by-同舟云学术

A core–shell structured polyplex for efficient and non-toxic gene delivery

Published:2017 Issue:26 Volume:5 Page:5101-5108
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Wang Saisai¹²³⁴⁵,Wang Fei⁶⁷⁸⁹¹⁰,Zhang Qiang¹²³⁴⁵,Cheng Yiyun¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Regulatory Biology

2. School of Life Sciences

3. East China Normal University

4. Shanghai

5. P. R. China

6. Shanghai Institute of Traumatology and Orthopaedics

7. Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine

8. Ruijin Hospital

9. Jiao Tong University School of Medicine

10. Shanghai 200025

Abstract

We developed a core–shell polyplex with minimal high generation dendrimer to condense DNA and low-molecular-weight linear polyethylenimine coated on the core. The polyplex represented both high transfection efficacy and low toxicity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TB/C7TB00690J

Reference48 articles.

1. Gene therapy finds its niche

2. Progress and prospects: hurdles to cardiovascular gene therapy clinical trials

3. Engineering adeno-associated viruses for clinical gene therapy

4. Design and development of polymers for gene delivery

5. Cationic lipids and polymers mediated vectors for delivery of siRNA

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