Identification, isolation, structural characterisation, synthesis and in silico toxicity prediction of the alkaline hydrolytic degradation product of brivaracetam by using LC-PDA, preparative HPLC, LC/HESI/LTQ, FTIR, and 1H NMR-Reference-Cited by-同舟云学术

Identification, isolation, structural characterisation, synthesis and in silico toxicity prediction of the alkaline hydrolytic degradation product of brivaracetam by using LC-PDA, preparative HPLC, LC/HESI/LTQ, FTIR, and 1H NMR

Published:2020 Issue:14 Volume:12 Page:1868-1881
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Bhamare Pankaj¹²³⁴,Umadoss P.¹²³⁴,Upmanyu Neeraj¹²³⁴,Dubey Rupal¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy and Research

2. People's University

3. Bhopal

4. India

Abstract

Brivaracetam is a racetam derivative of levetiracetam with very limited data available on its degradation behaviour.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/C9AY02582K

Reference73 articles.

1. Drugbank: Brivaracetam, [internet] available from https://www.drugbank.ca/drugs/DB05541

2. Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties

3. Briviact FDA Approval, [internet] available from, https://www.ucb.com/stories-media/press-releases/article/USFDA-approves-UCB-s-new-epilepsy-treatment-BRIVIACT-for-patients-with-partial-onset-seizures

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1. Correction: Identification, isolation, structural characterisation, synthesis and in silico toxicity prediction of the alkaline hydrolytic degradation product of brivaracetam by using LC-PDA, preparative HPLC, LC/HESI/LTQ, FTIR, and ¹H NMR;Analytical Methods;2024

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4. Stereodivergent Synthesis of Enantioenriched 2-Pyrrolidones via Diastereoselective Hydrogenation of ?,?-Unsaturated ?-Lactams;ORG LETT;2023

5. A Brief Review of Analytical Methods for the Estimation of Brivaracetam in Pharmaceutical Formulation and Biological Matrices;Journal of Advanced Zoology;2022-09-30