Antidiabetic profiling of veramycins, polyketides accessible by biosynthesis, chemical synthesis and precursor-directed modification-Reference-Cited by-同舟云学术

Antidiabetic profiling of veramycins, polyketides accessible by biosynthesis, chemical synthesis and precursor-directed modification

Published:2022 Issue:6 Volume:9 Page:1604-1615
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Dardić Denis¹,Böhringer Nils²³,Plaza Alberto¹,Zubeil Florian¹,Pohl Juliane¹²,Sommer Svenja¹²,Padva Leo¹²,Becker Jonathan²,Patras Maria A.¹,Bill Mona-Katharina¹,Kurz Michael⁴,Toti Luigi⁵,Görgens Sven W.⁴,Schuler Sören M. M.¹,Billion André¹,Schwengers Oliver²^ORCID,Wohlfart Paulus⁵,Goesmann Alexander²,Tennagels Norbert⁵,Vilcinskas Andreas¹²,Hammann Peter E.⁵,Schäberle Till F.¹²³^ORCID,Bauer Armin⁴^ORCID

Affiliation:

1. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, 35392 Gießen, Germany

2. Justus-Liebig-University Gießen, 35392 Gießen, Germany

3. German Center of Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, 35392 Gießen, Germany

4. Sanofi-Aventis Deutschland GmbH, R&D Integrated Drug Discovery, 65926 Frankfurt am Main, Germany

5. Sanofi-Aventis Deutschland GmbH, R&D German Hub, 65926 Frankfurt am Main, Germany

Abstract

New polyketides, termed veramycins, were isolated along with their known congeners NFAT-133 and TM-123. Total synthesis from a central building block was accomplished, the BGC identified and a biosynthetic pathway for this molecule class proposed.

Funder

Hessisches Ministerium für Wissenschaft und Kunst

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01652K

Reference30 articles.

1. Promise and challenges for direct small molecule AMPK activators

2. AMPK at the Nexus of Energetics and Aging

3. AMPK: Therapeutic Target for Diabetes and Cancer Prevention