Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis
Author:
Affiliation:
1. Stratingh Institute for Chemistry
2. University of Groningen
3. Groningen
4. The Netherlands
5. Department of Nuclear Medicine and Molecular Imaging
6. University Medical Center Groningen
7. 9713 GZ Groningen
8. Department of Radiology
Abstract
An efficient 11C-labelling method, using [11C]CH3Li for the labelling of a variety of PET-tracers via cross-coupling reaction is presented.
Funder
Koninklijke Nederlandse Akademie van Wetenschappen
Ministerie van Onderwijs, Cultuur en Wetenschap
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC05392A
Reference45 articles.
1. The preparation of 11C-methyl iodide and its use in the synthesis of 11C-methyl-L-methionine
2. Comparison of [11C]methyl triflate and [11C]methyl iodide in the synthesis of PET radioligands such as [11C]β-CIT and [11C]β-CFT
3. A simple synthesis of [11C]methyl triflate
4. Recent progress in [11 C]carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) chemistry
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