Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure-Reference-Cited by-同舟云学术

Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure

Published:2018 Issue:36 Volume:16 Page:6647-6651
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jiang Yan¹²³⁴⁵^ORCID,Yu Shuo-Wen⁵⁶⁷⁸⁴,Yang Yi¹²³⁴,Liu Ying-Le¹²³⁴,Xu Xiao-Ying⁵⁶⁷⁸⁴,Zhang Xiao-Mei⁵⁶⁷⁸⁴^ORCID,Yuan Wei-Cheng⁵⁶⁷⁸⁴^ORCID

Affiliation:

1. School of Chemistry and Environmental Engineering

2. Sichuan University of Science & Engineering

3. Zigong 643000

4. China

5. National Engineering Research Center of Chiral Drugs

6. Chengdu Institute of Organic Chemistry

7. Chinese Academy of Sciences

8. Chengdu 610041

Abstract

A general method for the synthesis of chiral pentacyclic spirooxindoles containing a tetrahydropyrano[2,3-b]indole scaffold through a one-pot stepwise sequence is reported.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

Education Department of Sichuan Province

Sichuan University of Science and Engineering

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01713A

Reference60 articles.

1. Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

2. Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

3. Therapeutic Potential of Spirooxindoles as Antiviral Agents

4. Spirooxindoles: Promising scaffolds for anticancer agents

5. Spirooxindoles as Potential Pharmacophores

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