High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat diet-induced obesity-Reference-Cited by-同舟云学术

High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat diet-induced obesity

Published:2021 Issue:23 Volume:12 Page:11819-11828
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Faradina Amelia¹,Tseng Sung-Hui²³,Tung Te-Hsuan¹,Huang Shih-Yi¹⁴⁵^ORCID,Lee Yu-Chieh⁶,Skalny Anatoly V.⁷,Tinkov Alexey A.⁷⁸^ORCID,Chen Seu-Hwa⁹,Chuang Yung-Kun¹⁰,Chang Jung-Su¹⁴¹¹¹²^ORCID

Affiliation:

1. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan

2. Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan

3. Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

4. Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan

5. Center for Reproductive Medicine & Sciences, Taipei Medical University Hospital, Taipei, Taiwan

6. Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan

7. Laboratory of Molecular Dietology, IM Sechenov First Moscow State Medical University (Sechenov University), 119146, Moscow, Russia

8. Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, 460000, Orenburg, Russia

9. Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

10. Master Program in Food Safety, College of Nutrition, Taipei Medical University, Taipei, Taiwan

11. Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan

12. Chinese Taipei Society for the Study of Obesity, CTSSO, Taipei, Taiwan

Abstract

High dose ferric citrate supplementation attenuated n-3 PUFAs biosynthesis in rats with HFD-induced obesity via downregulating Δ-6 and Δ-5 desaturases. Decreased n-3 PUFAs and the converting enzymes were correlated with levels of liver iron and MDA.

Funder

Taipei Medical University Hospital

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO02680A

Reference43 articles.

1. Obesity as an Emerging Risk Factor for Iron Deficiency

2. Serum Ferritin Levels Are Positively Associated With Metabolically Obese Normal Weight