A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides-Reference-Cited by-同舟云学术

A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides

Published:2017 Issue:79 Volume:53 Page:10926-10929
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ashokkumar Veeramanoharan¹²³⁴⁵,Siva Ayyanar¹²³⁴⁵^ORCID,Ramaswamy Chidambaram R.¹²³⁴⁵

Affiliation:

1. Supramolecular and Organometallic Chemistry Lab

2. Department of Inorganic Chemistry

3. School of Chemistry

4. Madurai Kamaraj University

5. Madurai

Abstract

A new class of proline based chiral organocatalysts was designed and efficient catalysts for asymmetric Darzens reaction to obtain active di- and tri-substituted epoxides with high yields (up to 97%) and excellent ee's (up to 99%) under mild reaction conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC06194C

Reference84 articles.

1. H. O. House , Modern Synthetic Reactions, Benjamin, Menlo Park, CA, 1972, p. 670

2. L. Ojima , Catalytic Asymmetric Synthesis, Wiley, New York, 2nd edn, 2000

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