Thermodynamic and kinetic investigation of monoketo-aldehyde-peroxyhemiacetal (MKA), a stereolabile degradation product of dihydroartemisinin-Reference-Cited by-同舟云学术

Thermodynamic and kinetic investigation of monoketo-aldehyde-peroxyhemiacetal (MKA), a stereolabile degradation product of dihydroartemisinin

Published:2014 Issue:62 Volume:4 Page:32847-32857
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Kotoni D.¹²³,Piras M.¹²³⁴⁵,Cabri W.⁶⁷⁸⁹,Giorgi F.⁶⁷⁸⁹,Mazzanti A.¹⁰¹¹¹²,Pierini M.¹²³,Quaglia M.⁶⁷⁸⁹,Villani C.¹²³,Gasparrini F.¹²³

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco

2. Sapienza Università di Roma

3. 00185 Roma, Italy

4. Kosterlitz Centre for Therapeutics

5. Institute of Medical Sciences

6. Analytical Development

7. R&D Department

8. Sigma-Tau S.p.A.

9. 00040 Pomezia, Italy

10. Dipartimento di Chimica Industriale “T. Montanari”

11. Università di Bologna

12. 40136 Bologna, Italy

Abstract

Theβ⇆αepimerization process ofMKAhas been studied under a thermodynamic and kinetic point of view in several solvents. LSER analyses and molecular modeling calculations allowed an effective rationalization of the findings.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA00879K

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