A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site

Published:2017 Issue:19 Volume:15 Page:4096-4114
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Burnett James C.¹²³⁴⁵,Lim Chaemin⁵⁶⁷⁴,Peyser Brian D.⁸⁹³⁴^ORCID,Samankumara Lalith P.⁵⁶⁷⁴,Kovaliov Marina⁵⁶⁷⁴,Colombo Raffaele⁵⁶⁷⁴,Bulfer Stacie L.¹⁰¹¹¹²¹³⁴,LaPorte Matthew G.⁵⁶⁷⁴,Hermone Ann R.¹²³⁴,McGrath Connor F.¹²³⁴,Arkin Michelle R.¹⁰¹¹¹²¹³⁴,Gussio Rick⁸⁹³⁴,Huryn Donna M.⁵⁶⁷⁴¹⁴,Wipf Peter⁵⁶⁷⁴¹⁴^ORCID

Affiliation:

1. Leidos Biomedical Research

2. Inc.

3. Frederick

4. USA

5. University of Pittsburgh Chemical Diversity Center

6. University of Pittsburgh

7. Pittsburgh

8. Frederick National Laboratory for Cancer Research

9. Developmental Therapeutics Program

10. Department of Pharmaceutical Chemistry

11. Small Molecule Discovery Center

12. University of California

13. San Francisco

14. Department of Pharmaceutical Sciences

Abstract

The turnstile motion of two neighboring threonines accommodates both polar and apolar ligands.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00526A

Reference29 articles.

1. Structure and function of the AAA+ ATPase p97/Cdc48p

2. Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97

3. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

4. Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

5. Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer;ACS Medicinal Chemistry Letters;2023-06-21

2. Inhibitors of the ATPase p97/VCP: From basic research to clinical applications;Cell Chemical Biology;2023-01

3. Anion Recognition with Antimony(III) and Bismuth(III) Triaryl‐Based Pnictogen Bonding Receptors;Chemistry – A European Journal;2022-10-11

4. The p97 Inhibitor UPCDC-30245 Blocks Endo-Lysosomal Degradation;Pharmaceuticals;2022-02-07

5. Affinity Capture of p97 with Small-Molecule Ligand Bait Reveals a 3.6 Å Double-Hexamer Cryoelectron Microscopy Structure;ACS Nano;2021-04-26

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3