Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds-Reference-Cited by-同舟云学术

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds

Published:2021 Issue:1 Volume:12 Page:62-72
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Liu Rui¹²³⁴,Markley Lowell¹²³⁴,Miller Patricia A.¹²³⁴,Franzblau Scott⁵⁶⁷⁸⁴,Shetye Gauri⁵⁶⁷⁸⁴,Ma Rui⁵⁶⁷⁸⁴,Savková Karin⁹¹⁰¹¹¹²¹³,Mikušová Katarína⁹¹⁰¹¹¹²¹³^ORCID,Lee Bei Shi¹⁴¹⁵¹⁶^ORCID,Pethe Kevin¹⁴¹⁵¹⁶¹⁷¹⁵,Moraski Garrett C.¹¹⁸¹⁹⁴,Miller Marvin J.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of Notre Dame

3. Notre Dame

4. USA

5. Institute for Tuberculosis Research

6. College of Pharmacy

7. University of Illinois at Chicago

8. Chicago

9. Department of Biochemistry

10. Faculty of Natural Sciences

11. Comenius University in Bratislava

12. 84215 Bratislava

13. Slovakia

14. School of Biological Sciences

15. Nanyang Technological University

16. Singapore 637551

17. Lee Kong Chian School of Medicine

18. Montana State University

19. Bozeman

Abstract

The formation efficiency of hydride-induced Meisenheimer complexes of nitroaromatic compounds is consistent with their anti-TB activities exemplied by MDL860 and benzothiazol N-oxide (BTO) analogs.

Funder

National Institute of Allergy and Infectious Diseases

University of Notre Dame

Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky

Agentúra na Podporu Výskumu a Vývoja

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00390E

Reference26 articles.